The Journal of Experimental Medicine Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
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چکیده
The authors noted that a reference regarding the suppressive effect of BMP7 on EMT and bone metastasis in prostate cancer was inadvertently omitted. The authors have added the following publication to the references: a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Am. The html and pdf versions of this article have been updated to reflect this change.
منابع مشابه
Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant organs are a critical issue. However, how metastatic tumor cells become dormant and how and why tumors recur in target organs are not well understood. In this study, we demonstrate that BMP7 (bone morphogenetic protein 7) secreted from bone stromal cells induces senescence in prostate cancer stem-like cells ...
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Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...
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Background Specific growth factors and feeder layers seem to have important roles in in vitro embryonic stem cells (ESCs) differentiation. In this study,the effects of bone morphogenetic protein 4 (BMP4) and mouse embryonic fibroblasts (MEFs) co-culture system on germ cell differentiation from mouse ESCs were studied. MaterialsAndMethods Cell suspension was prepared from one-day-old embryoid bo...
متن کاملTITLE: BMP7 Induces Dormancy of Prostatic Tumor Stem Cell in Bone PRINCIPAL INVESTIGATOR:
presentation 1. Aya Kobayashi, Hiroshi Okuda, Puspa R. Pandey, Misako Watabe, Sudha K. Pai, Shigeru Hirota, Fei Xing, Wen Liu, Bo Xia, Kounosuke Watabe Poster Presentation: “BMP7 regulates dormancy and recurrence of prostate cancer stem cell in bone” Joint MRS-AACR Conference: Metastasis and the Tumor Microenvironment, 2010, Philadelphia, PA 2. Aya Kobayashi, Hiroshi Okuda, Puspa Pandey, Misako...
متن کاملComparison of Cell Viability and Embryoid Body Size of Two Embryonic Stem Cell Lines After Different Exposure Times to Bone Morphogenetic Protein 4
Background: Activation of bone morphogenetic protein 4 (BMP4) signaling pathway in embryonic stem (ES) cells plays an important role in controlling cell proliferation, differentiation, and apoptosis. Adverse effects of BMP4 occur in a time dependent manner; however, little is known about the effect of different time exposure of this growth factor on cell number in culture media. In this study, ...
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تاریخ انتشار 2012